COVID-19 Jab Does Not Work. Here’s Why

Covid

BY Joe Wang and Jennifer Margulis TIME July 11, 2022

A team of Harvard research scientists, publishing in the New England Journal of Medicine, have found that SARS-CoV-2 virus has mutated so much that the Pfizer mRNA vaccines developed against the original Wuhan strain now have little to no effect.

The study, “Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5,” evaluated neutralizing antibody titers of participants vaccinated with the Pfizer vaccine, against multiple SARS-CoV-2 strains.

The scientists found that the titers dropped from 5,783 (against the WA1/2020 isolate, Wuhan strain) to 275 (against the BA.4 or BA.5 subvariant, omicron variants), by a factor of 21.

In other words, they found the mRNA vaccine to be essentially ineffective against Omicron variants currently in circulation.

SARS-CoV-2 Mutations

SARS-CoV-2 has been a quickly evolving virus since late 2019. Like all RNA viruses, it has a strand of RNA that is packaged in a delivery vehicle that allows it to attach itself to host cells and inject its RNA into the cells and hijack the cells to make more copies of its RNA.

A virus must interact with living cells in order to reproduce. Without this interaction, the virus itself is inert. It has no metabolism. It cannot move. It doesn’t eat. It cannot reproduce with other viruses. What this means is that a virus has none of the characteristics of living organisms. Because of this, some scientists want to classify viruses as part of life while others point out that viruses are not alive. At least not without hosts.

Life or not, all viruses must have genetic material RNA (ribonucleic acid) or DNA (deoxyribonucleic acid). RNA or DNA make copies using templates of complementary strands of RNA or DNA. There is always a chance for errors to happen during this process. We call these “errors” mutations.

Often these errors make the DNA or RNA too imperfect to carry on functioning, so the mutation goes nowhere. But if the mutated version is viable, the result is a new, slightly changed version of the DNA or RNA.

A virus that does not kill its host but is able to keep using the host to replicate itself is able to continue replicating. There is an advantage to a virus developing a way to become chronic or endemic, rather than being rabidly lethal to the host.

By every indication, that is what is happening with SARS-CoV-2, the novel virus that likely originated in Wuhan, China, and quickly spread around the globe, using humans and other animals as its host.

Anti-Spike Antibodies

Many of the mutations to the SARS-CoV-2 RNA do not change any of the proteins the virus needs to survive and proliferate. These are called silent or synonymous mutations. Others, known to scientists as non-synonymous mutations, do change the amino acid composition of the proteins.

The amino acid sequence differences (about 3 percent) observed between SARS-CoV-2 spike proteins from the original Wuhan strain (GenBank # YP_009724390) and an Omicron isolate from Norway on January 3rd, 2022 (GenBank # UOU35996.1) are the results of two years of evolution of the virus on its spike protein.

Epoch Times Photo
(National Library of Medicine’s online Blast service)

Using the National Library of Medicine’s online Blast service, the authors compared the spike protein sequences from the Wuhan strain and an Omicron variant. The red lines highlight the mismatches.

Compared to other parts of the virus genome, the gene that codes for the spike protein evolve faster, as the spike protein is on the surface of the virus and is under much more selection pressure.

This poses a problem for the current vaccines and any future vaccines based on the spike protein. The fast-changing spike protein would likely make the existing vaccines and any new vaccines less effective. In other words, the virus has moved on, but the vaccines have not.

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